TPM4
TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.96, genetic association 0.19, somatic mutation 0.80, animal model 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
- 3 · How drugs use it
No product in this corpus aims at TPM4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12013 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P67936 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167460 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Binds calcium. Plays a role in platelet biogenesis. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.12-p13.11 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TPM4" OR ABSTRACT:"TPM4" OR TITLE:"tropomyosin 4" OR ABSTRACT:"tropomyosin 4" OR TITLE:"Tropomyosin alpha-4 chain" OR ABSTRACT:"Tropomyosin alpha-4 chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPM4, not a curated reading list.