TPT1
TPT1 (Translationally-controlled tumour protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Overview
Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sertraline.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TPT1 (Translationally-controlled tumour protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
- 1 · What it is
TPT1 (Translationally-controlled tumour protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
- 2 · What goes wrong in cancer
Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein.
- 3 · How drugs use it
No product in this corpus aims at TPT1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12022 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P13693 (protein name, function text, keywords and locations (REST API)); CIViC gene TPT1 (1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0))
Biology
Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein. Location: Cytoplasm (UniProt). Locus 13q14.13 (HGNC).
- Melanoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TPT1" OR ABSTRACT:"TPT1" OR TITLE:"tumor protein, translationally-controlled 1" OR ABSTRACT:"tumor protein, translationally-controlled 1" OR TITLE:"Translationally-controlled tumor protein" OR ABSTRACT:"Translationally-controlled tumor protein" OR TITLE:"fortilin" OR ABSTRACT:"fortilin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPT1, not a curated reading list.