TUBB3
TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
Overview
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Paclitaxel and Taxane Compound. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes clinical 1.00, affected pathway 0.61, literature 0.95, genetic association 0.28, somatic mutation 0.23, animal model 0.36).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
- 1 · What it is
TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.
- 2 · What goes wrong in cancer
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms.
- 3 · How drugs use it
No product in this corpus aims at TUBB3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:20772 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13509 (protein name, function text, keywords and locations (REST API)); CIViC gene TUBB3 (2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Cancer (GraphQL API, CC0)); Open Targets ENSG00000258947 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.55, prostate cancer 0.63, ovarian cancer 0.58, cervical cancer 0.59, head and neck squamous cell carcinoma 0.54 (GraphQL API, CC0))
Biology
Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerised TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Location: Cytoplasm, cytoskeleton; Cell projection, growth cone; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 16q24.3 (HGNC).
- Breast cancer: Open Targets association 0.63 with breast cancer (MONDO_0007254); CIViC evidence names this disease
- Lung cancer: Open Targets association 0.63 with lung cancer (MONDO_0008903)
- Prostate cancer: Open Targets association 0.63 with prostate cancer (MONDO_0008315)
- Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)
- Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)
- Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00; CIViC holds 2 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TUBB3" OR ABSTRACT:"TUBB3" OR TITLE:"tubulin beta 3 class III" OR ABSTRACT:"tubulin beta 3 class III" OR TITLE:"Tubulin beta-3 chain" OR ABSTRACT:"Tubulin beta-3 chain" OR TITLE:"beta-4" OR ABSTRACT:"beta-4" OR TITLE:"CFEOM3" OR ABSTRACT:"CFEOM3" OR TITLE:"CFEOM3A" OR ABSTRACT:"CFEOM3A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB3, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTUBA1A
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBA1B
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBA1C
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBA3C
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBA3E
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBA4A
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBB1
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).
- TargetTUBB2A
Shares Hodgkin lymphoma, Lung cancer (all types), Non-Hodgkin lymphoma (all types), Sarcomas (soft tissue, bone, GIST).