TYRP1
TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Overview
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.56, animal model 0.63, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 1 · What it is
TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 2 · What goes wrong in cancer
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+).
- 3 · How drugs use it
No product in this corpus aims at TYRP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:12450 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107165 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: skin cancer 0.53 (GraphQL API, CC0))
Biology
Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Location: Melanosome membrane (UniProt). Locus 9p23 (HGNC).
- Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TYRP1" OR ABSTRACT:"TYRP1" OR TITLE:"tyrosinase related protein 1" OR ABSTRACT:"tyrosinase related protein 1" OR TITLE:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR ABSTRACT:"5,6-dihydroxyindole-2-carboxylic acid oxidase" OR TITLE:"GP75" OR ABSTRACT:"GP75" OR TITLE:"b-PROTEIN" OR ABSTRACT:"b-PROTEIN" OR TITLE:"OCA3" OR ABSTRACT:"OCA3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYRP1, not a curated reading list.