UBTF
UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
Overview
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape.
CIViC holds 1 clinical evidence item and 2 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
- 1 · What it is
UBTF (Nucleolar transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
- 2 · What goes wrong in cancer
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex.
- 3 · How drugs use it
No product in this corpus aims at UBTF yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:12511 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17480 (protein name, function text, keywords and locations (REST API)); CIViC gene UBTF (1 evidence items, 2 assertions, 1 variants; diseases: Acute Myeloid Leukaemia (GraphQL API, CC0))
Biology
Recognises the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. Location: Nucleus, nucleolus (UniProt). Locus 17q21.31 (HGNC).
- Acute myeloid leukaemia: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"UBTF" OR ABSTRACT:"UBTF" OR TITLE:"upstream binding transcription factor" OR ABSTRACT:"upstream binding transcription factor" OR TITLE:"Nucleolar transcription factor 1" OR ABSTRACT:"Nucleolar transcription factor 1" OR TITLE:"NOR-90" OR ABSTRACT:"NOR-90" OR TITLE:"UBF1" OR ABSTRACT:"UBF1" OR TITLE:"UBF2" OR ABSTRACT:"UBF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about UBTF, not a curated reading list.