UGT1A
UGT1A (UDP glucuronosyltransferase family 1 member A complex locus) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
UniProt has no function text for this gene; HGNC names it "UDP glucuronosyltransferase family 1 member A complex locus".
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Ganetespib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · UGT1A (UDP glucuronosyltransferase family 1 member A complex locus) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
UGT1A (UDP glucuronosyltransferase family 1 member A complex locus) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for this gene; HGNC names it "UDP glucuronosyltransferase family 1 member A complex locus". Locus 2q37 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at UGT1A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12529 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); CIViC gene UGT1A (1 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Biology
UniProt has no function text for this gene; HGNC names it "UDP glucuronosyltransferase family 1 member A complex locus". Locus 2q37 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"UGT1A" OR ABSTRACT:"UGT1A" OR TITLE:"UDP glucuronosyltransferase family 1 member A complex locus" OR ABSTRACT:"UDP glucuronosyltransferase family 1 member A complex locus" OR TITLE:"UGT1A@" OR ABSTRACT:"UGT1A@") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about UGT1A, not a curated reading list.