VCL
VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex.
- 3 · How drugs use it
No product in this corpus aims at VCL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12665 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P18206 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000035403 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Location: Cell membrane; Cell junction, adherens junction; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10q22.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VCL" OR ABSTRACT:"VCL" OR TITLE:"vinculin" OR ABSTRACT:"vinculin" OR TITLE:"Vinculin" OR ABSTRACT:"Vinculin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VCL, not a curated reading list.