VPS53
VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, genetic association 0.69).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
- 3 · How drugs use it
No product in this corpus aims at VPS53 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25608 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VIR6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141252 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.53 (GraphQL API, CC0))
Biology
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalised transferrin receptor (TFRC) to the plasma membrane. Location: Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Recycling endosome (UniProt). Locus 17p13.3 (HGNC).
- Prostate cancer: Open Targets association 0.53 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VPS53" OR ABSTRACT:"VPS53" OR TITLE:"VPS53 subunit of GARP complex" OR ABSTRACT:"VPS53 subunit of GARP complex" OR TITLE:"Vacuolar protein sorting-associated protein 53 homolog" OR ABSTRACT:"Vacuolar protein sorting-associated protein 53 homolog" OR TITLE:"FLJ10979" OR ABSTRACT:"FLJ10979" OR TITLE:"HCCS1" OR ABSTRACT:"HCCS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VPS53, not a curated reading list.