VWF
VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.97, animal model 0.53, genetic association 0.31).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V.
- 3 · How drugs use it
No product in this corpus aims at VWF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12726 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04275 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110799 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Biology
Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma. Location: Secreted; Secreted, extracellular space, extracellular matrix (UniProt). Locus 12p13.31 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VWF" OR ABSTRACT:"VWF" OR TITLE:"von Willebrand factor" OR ABSTRACT:"von Willebrand factor" OR TITLE:"F8VWF" OR ABSTRACT:"F8VWF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VWF, not a curated reading list.