WDR12
WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Overview
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
- 1 · What it is
WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at WDR12 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:14098 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9GZL7 (protein name, function text, keywords and locations (REST API)); CIViC gene WDR12 (1 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0))
Biology
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 2q33.2 (HGNC).
- Glioma & glioblastoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"WDR12" OR ABSTRACT:"WDR12" OR TITLE:"WD repeat domain 12" OR ABSTRACT:"WD repeat domain 12" OR TITLE:"Ribosome biogenesis protein WDR12" OR ABSTRACT:"Ribosome biogenesis protein WDR12" OR TITLE:"YTM1" OR ABSTRACT:"YTM1" OR TITLE:"FLJ10881" OR ABSTRACT:"FLJ10881") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WDR12, not a curated reading list.