XRCC2
XRCC2 (DNA repair protein XRCC2) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.87, genetic association 0.74, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · XRCC2 (DNA repair protein XRCC2) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
XRCC2 (DNA repair protein XRCC2) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
- 3 · How drugs use it
No product in this corpus aims at XRCC2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:12829 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43543 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196584 (association with cancer (MONDO_0004992) 0.70; (GraphQL API, CC0))
Biology
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 7q36.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"XRCC2" OR ABSTRACT:"XRCC2" OR TITLE:"X-ray repair cross complementing 2" OR ABSTRACT:"X-ray repair cross complementing 2" OR TITLE:"DNA repair protein XRCC2" OR ABSTRACT:"DNA repair protein XRCC2" OR TITLE:"FANCU" OR ABSTRACT:"FANCU") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about XRCC2, not a curated reading list.