ZFHX4
ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, animal model 0.43, genetic association 0.63).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
ZFHX4 (Zinc finger homeobox protein 4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.
- 3 · How drugs use it
No product in this corpus aims at ZFHX4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:30939 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UP3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000091656 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
May play a role in neural and muscle differentiation. May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZFHX4" OR ABSTRACT:"ZFHX4" OR TITLE:"zinc finger homeobox 4" OR ABSTRACT:"zinc finger homeobox 4" OR TITLE:"Zinc finger homeobox protein 4" OR ABSTRACT:"Zinc finger homeobox protein 4" OR TITLE:"ZFH4" OR ABSTRACT:"ZFH4" OR TITLE:"FLJ20980" OR ABSTRACT:"FLJ20980") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZFHX4, not a curated reading list.