ZNF292
ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Overview
May be involved in transcriptional regulation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 1 · What it is
ZNF292 (Zinc finger protein 292) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZNF292 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:18410 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60281 (protein name, function text, keywords and locations (REST API)); CIViC gene ZNF292 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 6q14.3 (HGNC).
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF292" OR ABSTRACT:"ZNF292" OR TITLE:"zinc finger protein 292" OR ABSTRACT:"zinc finger protein 292" OR TITLE:"Zinc finger protein 292" OR ABSTRACT:"Zinc finger protein 292" OR TITLE:"KIAA0530" OR ABSTRACT:"KIAA0530" OR TITLE:"ZFP292" OR ABSTRACT:"ZFP292" OR TITLE:"bA393I2.3" OR ABSTRACT:"bA393I2.3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF292, not a curated reading list.