ZNF462
ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.17, animal model 0.34, genetic association 0.77).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
ZNF462 (Zinc finger protein 462) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG.
- 3 · How drugs use it
No product in this corpus aims at ZNF462 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:21684 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96JM2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000148143 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Biology
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organisation. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerisation of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation. Location: Nucleus (UniProt). Locus 9q31.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZNF462" OR ABSTRACT:"ZNF462" OR TITLE:"zinc finger protein 462" OR ABSTRACT:"zinc finger protein 462" OR TITLE:"Zinc finger protein 462" OR ABSTRACT:"Zinc finger protein 462" OR TITLE:"DKFZP762N2316" OR ABSTRACT:"DKFZP762N2316" OR TITLE:"KIAA1803" OR ABSTRACT:"KIAA1803" OR TITLE:"Zfp462" OR ABSTRACT:"Zfp462") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF462, not a curated reading list.