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Software that finds dividing cells on a digitised biopsy slide and counts them. The count is part of how many cancers are graded, and people counting by eye often disagree.
The mitotic count is a component of the Nottingham grade of breast cancer and of risk scores for tumours such as gastrointestinal stromal tumours, and pathologists agree on it poorly. Automated detection on whole-slide images has been driven by open challenges. TUPAC16 (Veta and colleagues, Medical Image Analysis 2019) asked teams to predict mitotic scores from 821 breast cancer whole-slide images; the best method reached a quadratic-weighted kappa of 0.567 against the reference. The MIDOG 2021 challenge (Aubreville and colleagues, Medical Image Analysis 2023) targeted the drop in accuracy when a model meets a new slide scanner: trained on 200 cases from four scanners and tested on 100 cases including two unseen scanners, the winning algorithm reached an F1 score of 0.748 (95 per cent CI 0.704 to 0.781), above six experts on the same task.
Mitosis counting is one task within broader AI pathology scoring. The barrier to use is generalisation across scanners, stains and laboratories, and validation of grades rather than counts against patient outcomes.
Object detection networks scan high-power fields of a whole-slide image for mitotic figures, distinguish them from look-alikes (apoptotic and pyknotic nuclei), and aggregate counts per area into a score or grade component.
Query for this technology: (TITLE:"AI mitosis detection and grading" OR ABSTRACT:"AI mitosis detection and grading" OR TITLE:"mitotic figure detection" OR ABSTRACT:"mitotic figure detection" OR TITLE:"AI mitotic count" OR ABSTRACT:"AI mitotic count" OR TITLE:"automated mitosis counting" OR ABSTRACT:"automated mitosis counting") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AI mitosis detection and grading, not a curated reading list.
Shares AI scoring of biomarkers and grade on pathology slides, Digital pathology & AI, Breast cancer (all types).
Shares AI scoring of biomarkers and grade on pathology slides, Digital pathology & AI, Breast cancer (all types).
Shares Digital pathology and whole-slide images (WSI), Digital pathology & AI.
Shares Nottingham grade (breast cancer grade 1, 2 and 3), Grade, Breast cancer (all types).
Shares Mitosis & the spindle assembly checkpoint, Breast cancer (all types).
Shares Nottingham grade (breast cancer grade 1, 2 and 3), Grade, Breast cancer (all types).
Shares Grade, Breast cancer (all types).
Shares Nottingham grade (breast cancer grade 1, 2 and 3), Breast cancer (all types).
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