BUB1B
BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
Overview
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.68, literature 0.98, genetic association 0.55, somatic mutation 0.89, animal model 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
- 1 · What it is
BUB1B (Mitotic checkpoint serine/threonine-protein kinase BUB1 beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer, Breast cancer and 3 more.
- 2 · What goes wrong in cancer
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle.
- 3 · How drugs use it
No product in this corpus aims at BUB1B yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:1149 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60566 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156970 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.57, gastric cancer 0.50, ovarian cancer 0.51, melanoma 0.52, skin cancer 0.55, breast cancer 0.53 (GraphQL API, CC0))
Biology
Kinase which is a component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle. The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint. The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition. When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase. MCC also monitors kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localisation of CENPE. Location: Cytoplasm; Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 15q15.1 (HGNC).
- Colorectal cancer: Open Targets association 0.57 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)
- Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BUB1B" OR ABSTRACT:"BUB1B" OR TITLE:"BUB1 mitotic checkpoint serine/threonine kinase B" OR ABSTRACT:"BUB1 mitotic checkpoint serine/threonine kinase B" OR TITLE:"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" OR ABSTRACT:"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta" OR TITLE:"BUBR1" OR ABSTRACT:"BUBR1" OR TITLE:"MAD3L" OR ABSTRACT:"MAD3L" OR TITLE:"Bub1A" OR ABSTRACT:"Bub1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BUB1B, not a curated reading list.
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