MXI1
MXI1 (Max-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.76, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MXI1 (Max-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
MXI1 (Max-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'.
- 3 · How drugs use it
No product in this corpus aims at MXI1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7534 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50539 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000119950 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: prostate cancer 0.59 (GraphQL API, CC0))
Biology
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX. Location: Nucleus (UniProt). Locus 10q25.2 (HGNC).
- Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MXI1" OR ABSTRACT:"MXI1" OR TITLE:"MAX interactor 1, dimerization protein" OR ABSTRACT:"MAX interactor 1, dimerization protein" OR TITLE:"Max-interacting protein 1" OR ABSTRACT:"Max-interacting protein 1" OR TITLE:"MXD2" OR ABSTRACT:"MXD2" OR TITLE:"MAD2" OR ABSTRACT:"MAD2" OR TITLE:"bHLHc11" OR ABSTRACT:"bHLHc11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MXI1, not a curated reading list.
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