RPS27
RPS27 (Small ribosomal subunit protein eS27) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.09, genetic literature 0.76, clinical 0.11).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RPS27 (Small ribosomal subunit protein eS27) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
RPS27 (Small ribosomal subunit protein eS27) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
- 3 · How drugs use it
No product in this corpus aims at RPS27 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10416 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P42677 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177954 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for proper rRNA processing and maturation of 18S rRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 1q21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RPS27" OR ABSTRACT:"RPS27" OR TITLE:"ribosomal protein S27" OR ABSTRACT:"ribosomal protein S27" OR TITLE:"Small ribosomal subunit protein eS27" OR ABSTRACT:"Small ribosomal subunit protein eS27" OR TITLE:"MPS-1" OR ABSTRACT:"MPS-1" OR TITLE:"MPS1" OR ABSTRACT:"MPS1" OR TITLE:"S27" OR ABSTRACT:"S27") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS27, not a curated reading list.