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Ban Xia Xie Xin Tang, known in Japan as hangeshashinto, is a seven-herb Chinese and Japanese formula for indigestion. Small studies suggest it may help prevent delayed diarrhoea from irinotecan, radiation bowel inflammation and mouth ulcers from chemotherapy, but larger and more rigorous trials are needed.
The formula, from classical Chinese medical texts and made as a standardised Kampo product in Japan, contains prepared pinellia, dried ginger, Chinese skullcap (huang qin), goldthread (huang lian), Asian ginseng, Chinese date and honey-baked licorice. Memorial Sloan Kettering's About Herbs summary reports systematic reviews supporting its use in reflux, functional dyspepsia and gastritis, and findings that it may help prevent chemotherapy-induced delayed diarrhoea, acute radiation enteritis and chemotherapy-induced oral mucositis; it is among the most prescribed herbal formulas for people with colon cancer in Taiwan. Associations with lower colon cancer risk in people with diabetes and better survival after gastric cancer surgery are observational. MSK concludes that larger trials with methodological rigour are needed. Because it contains ginger and Asian ginseng, MSK advises against using it around surgery because of bleeding risk; reported side effects include nausea, headache, abdominal pain, diarrhoea and constipation. Licorice, one of its herbs, can lower potassium at high doses.
Baicalin from skullcap is proposed to reduce the gut conversion of irinotecan's metabolite to its toxic form and to dampen mucosal inflammation; the other herbs act on gut motility and inflammation.
Query for this technology: (TITLE:"Ban Xia Xie Xin Tang" OR ABSTRACT:"Ban Xia Xie Xin Tang" OR TITLE:"Hangeshashinto" OR ABSTRACT:"Hangeshashinto" OR TITLE:"TJ-14" OR ABSTRACT:"TJ-14" OR TITLE:"Banxia Xiexin Decoction" OR ABSTRACT:"Banxia Xiexin Decoction") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Ban Xia Xie Xin Tang (Hangeshashinto), not a curated reading list.
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Shares Traditional Chinese herbal medicine alongside treatment, Evidence-based integrative oncology and the tags complementary, supportive-care.
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