Cryopreservation and cell-therapy cold chain
Freezing cells at minus 150 degrees and shipping them in liquid-nitrogen 'dry shippers' with tracking, so a living drug arrives alive and matched to the right patient.
Cryoport, BioLife Solutions (CryoStor media, evo shippers), Cryoport's CRYOPDP, World Courier (Cencora), and Marken (UPS) provide validated cryogenic logistics with temperature and location telemetry; chain-of-identity and chain-of-custody software (Vineti, TrakCel, Ori, Kite's Konnect) links apheresis, manufacturing, and infusion. Failures here are rare but catastrophic for an individualised product.
How it works
Controlled-rate freezing in DMSO-based media, storage below -150°C in vapour-phase nitrogen, and GPS/temperature-logged dry shippers with digital identity verification at each hand-off.
- Enables centralised manufacturing across continents
- Full audit trail
- Cost per shipment
- Cryo-injury reduces viability
- Dependence on a few specialist couriers
Latest papers
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