ctDNA monitoring in lymphoma (PhasED-seq, clonoSEQ)
A blood test that tracks lymphoma DNA far below what a PET scan can see, so doctors can tell early who is cured and who will relapse.
Phased variant enrichment and detection sequencing (PhasED-seq, Foresight CLARITY) detects lymphoma ctDNA to parts-per-million by tracking multiple mutations on the same DNA fragment. End-of-treatment undetectable ctDNA predicts cure in DLBCL better than PET in several cohorts; ctDNA-guided escalation and de-escalation trials are opening. clonoSEQ tracks the clonal immunoglobulin rearrangement.
How it works
Deep sequencing of plasma cell-free DNA for tumour-specific mutations or the clonal IG rearrangement, with error suppression via phased variants.
- Sensitivity below PET detection
- Serial, non-invasive, interpretable in days
- Not yet a regulatory endpoint in DLBCL
- Requires baseline tumour profile
Latest papers
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not linked directly; found by shared links- PersonAsh A. Alizadeh
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