Histotripsy as an immune primer
Destroying a tumour mechanically with sound, rather than heat, leaves the debris intact enough for the immune system to learn from it.
Histotripsy liquefies tissue by cavitation without heating, so tumour antigens and danger signals survive in a form that heat coagulation destroys. Preclinical models show abscopal responses and synergy with checkpoint blockade, and the approved liver device provides a clinical platform. Human immune data are early and no randomised combination trial has reported.
How it works
Microsecond ultrasound pulses generate a cavitation bubble cloud that mechanically fractionates tissue at the focus, releasing intact antigens and danger signals that prime an immune response.
- Non-thermal, so antigens survive
- Non-invasive and repeatable
- Approved hardware already installed in hospitals
- Immune effect unproven in humans
- Acoustic window limits which tumours can be treated
- No randomised combination data
Latest papers
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