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SAM-e is sold for mood, joints and the liver. Evidence for depression is mixed, it did not help hot flushes, and small studies of protecting the liver during chemotherapy need confirming. It can trigger mania in bipolar disorder and adds to the serotonin effects of antidepressants.
S-adenosylmethionine is the body's main methyl donor and is involved in making serotonin and noradrenaline; it is a supplement in the United States and a prescription drug in some other countries. Memorial Sloan Kettering's About Herbs entry finds mixed data for depression, whether as an add-on or compared with escitalopram, with several double-blind studies negative; results for osteoarthritis are mixed, and an expert panel found insufficient evidence for pain. For hot flushes SAM-e was ineffective compared with historical placebo. In liver disease some trials suggest benefit, but in hepatitis C cirrhosis at high risk of liver cancer it did not improve liver function or injury markers. Preliminary data suggest it may help as palliative adjunct therapy in advanced biliary tract cancer or protect against chemotherapy liver toxicity; these need confirming. It is generally well tolerated but has caused mania in people with bipolar disorder and serotonin syndrome with clomipramine; MSK advises avoiding it with antidepressants, 5-HTP or St John's wort, notes it may reduce the effect of levodopa, and flags a theoretical concern about Pneumocystis infection in immunocompromised people.
Donates methyl groups for neurotransmitter, phospholipid and glutathione synthesis; poorly absorbed, so enteric-coated tablets are used.
Query for this technology: (TITLE:"SAM-e" OR ABSTRACT:"SAM-e" OR TITLE:"S-adenosylmethionine" OR ABSTRACT:"S-adenosylmethionine" OR TITLE:"SAMe" OR ABSTRACT:"SAMe" OR TITLE:"S-adenosyl-L-methionine" OR ABSTRACT:"S-adenosyl-L-methionine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SAM-e (S-adenosylmethionine), not a curated reading list.
Shares 5-HTP (5-hydroxytryptophan), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares N-acetylcysteine (NAC) supplements, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Psycho-oncology and distress screening, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares N-acetylcysteine (NAC) supplements, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares 5-HTP (5-hydroxytryptophan), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Psycho-oncology and distress screening and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
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