scGPT
A GPT-style model for single-cell data that predicts cell types, perturbation responses, and gene networks.
Nature Methods 2024: pretrained on 33M cells; fine-tunes for annotation, batch integration, perturbation prediction and gene regulatory inference.
Generic schematic · not to scale · placeholder for the ai computation front
Flagged finding · Neural network
How it works
scGPT is a generative transformer over gene tokens and expression bins.
Strengths
- General-purpose fine-tuning
Limitations
- Perturbation prediction only modestly above baselines
Since
2024
Latest papers
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