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Baikal skullcap is a Chinese herb used for hepatitis, infections and cancer, and was one of the herbs in PC-SPES. Its compounds kill cancer cells in the laboratory, but it has not been tested as a cancer treatment in people, and formulas containing it have caused acute liver injury. It lowered statin levels in healthy volunteers.
Scutellaria baicalensis root is used in traditional Chinese medicine, often in combinations such as PC-SPES and sho-saiko-to. Memorial Sloan Kettering's About Herbs summary reports that its compounds cause apoptosis in cancer cells and protect against doxorubicin heart toxicity in preclinical work, but that the root and its main flavonoid baicalin have dose-dependent pro- and anti-angiogenic effects. Human studies are limited to a preliminary diabetes study with metformin and an osteoarthritis supplement containing the herb; none tests it in cancer. MSK lists hepatotoxicity and pneumonitis as adverse reactions, with case reports of acute liver injury in people with arthritis taking baicalin-containing formulas. In healthy volunteers baicalin decreased blood levels of statins; it may add to anticoagulants and inhibits CYP1A2, CYP2C19 and drug-uptake transporters in vitro, of unknown clinical relevance.
Flavones baicalin, baicalein and wogonin are anti-inflammatory and pro-apoptotic in cell culture, with effects on blood vessel growth that change direction with dose.
Query for this technology: (TITLE:"Baikal skullcap" OR ABSTRACT:"Baikal skullcap" OR TITLE:"Scutellaria baicalensis" OR ABSTRACT:"Scutellaria baicalensis" OR TITLE:"Huang qin" OR ABSTRACT:"Huang qin" OR TITLE:"Chinese skullcap" OR ABSTRACT:"Chinese skullcap") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Baikal skullcap (Scutellaria baicalensis), not a curated reading list.
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Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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