AR-V7 splice variant

A truncated form of the androgen receptor that is permanently switched on and ignores hormone-blocking pills.

Lacks the ligand-binding domain; detected in circulating tumour cells (Epic Sciences nuclear AR-V7 test) and associated with resistance to abiraterone/enzalutamide but preserved taxane sensitivity. Rationale for N-terminal domain inhibitors (masofaniten, failed) and AR degraders.

Resistance: what this kind of term is about · animated schematic, not to scale