termsTerm
Hallmark: avoiding immune destruction
Cancers hide from or switch off the immune system, by losing the molecules that display their antigens or by raising checkpoint brakes.
MHC/B2M loss, JAK mutations, PD-L1 expression, Treg and myeloid recruitment, TGF-β exclusion. The hallmark behind checkpoint inhibitors, cell therapies, vaccines, and engagers.
Cancer biology: what this kind of term is about · animated schematic, not to scale
Category
Cancer biology
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