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Hallmark (2022): senescent cells

Cells that have permanently stopped dividing but stay alive and secrete inflammatory signals, helping nearby cancer cells grow and resist treatment.

Senescence-associated secretory phenotype from stromal and tumour cells after therapy; senolytics aim to clear them (one-two punch).

Cancer biology: what this kind of term is about · animated schematic, not to scale

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reviewCancer Discovery 2022

Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells

Cancer is now understood to change its identity and behaviour without new mutations, to be shaped by bacteria inside and around it, and to be helped along by ageing cells. This explains why some tumours escape targeted drugs by changing cell type and why gut bacteria affect immunotherapy response.

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Hallmark (2022): senescent cells

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