One-two punch: clear senescent cells after chemotherapy
Chemotherapy leaves behind senescent cells that inflame tissues and help tumours relapse. A short course of senolytic drugs afterwards might reduce relapse and long-term side effects at once.
Therapy-induced senescence and SASP promote relapse, cachexia, and frailty in models; senolytics (navitoclax, BCL-XL PROTACs, dasatinib+quercetin) clear them in mice; uPAR CAR-T clears senescent cells preclinically.
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