OnCo
termsTerm

Curative intent vs palliative intent

aka curative intent, curative-intent, curative, curable, potentially curable, cure rate, with curative intent, palliative intent, palliative, palliation, palliative chemotherapy, palliative treatment, non-curative, life-prolonging, best supportive care, BSC, supportive care alone, symptom control

Whether the goal of treatment is to eliminate the cancer for good (curative) or to control it, relieve symptoms and extend life when cure is not possible (palliative). The intent, not the drug, defines the word: the same chemotherapy can be either.

Curative-intent treatment usually combines surgery or radiotherapy with systemic therapy for localised or locally advanced disease and accepts more toxicity for a chance of cure; palliative-intent treatment for metastatic disease balances life extension against quality of life, and includes palliative radiotherapy for pain or bleeding and palliative surgery for obstruction. Best supportive care means symptom management without anticancer treatment and is the comparator in some trials. A growing minority of metastatic settings (oligometastatic disease, germ cell tumours, some lymphomas, MSI-high colorectal cancer on immunotherapy) blur the line, and early palliative care alongside curative or life-prolonging treatment improves outcomes.

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Treatment jargon

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