termsTerm
Dual HER2 blockade
Using two HER2 antibodies (trastuzumab and pertuzumab) at once, which works better than one.
Trastuzumab (domain IV) plus pertuzumab (domain II) block ligand-independent and ligand-dependent signalling and enhance ADCC. CLEOPATRA (OS +16 months), NeoSphere (pCR), and APHINITY (node-positive iDFS) established it; Phesgo delivers both subcutaneously. Now being paired with T-DXd (DESTINY-Breast09) and tucatinib (HER2CLIMB-05).
Pharmacology: what this kind of term is about · animated schematic, not to scale
Category
Pharmacology