Hallmark: sustaining proliferative signalling
Cancer cells keep telling themselves to divide, by making their own growth signals or jamming the receptors on.
Achieved via receptor mutation/amplification (EGFR, HER2, ALK), downstream activation (KRAS, BRAF, PIK3CA), or autocrine ligand production. The hallmark behind kinase inhibitors, HER2 antibodies, and RAS drugs.
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not linked directly; found by shared links- TermHallmark: enabling replicative immortality
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: resisting cell death
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: inducing or accessing vasculature
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: evading growth suppressors
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: activating invasion and metastasis
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermEnabling characteristic: genome instability and mutation
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark (2022): senescent cells
Shares Hallmarks of Cancer and the tag hallmark.
- TermHallmark (2022): non-mutational epigenetic reprogramming
Shares Hallmarks of Cancer and the tag hallmark.