TACE (transarterial chemoembolisation)
Threading a catheter into the artery feeding a liver tumour and injecting chemotherapy plus particles that block the blood supply, starving and poisoning it at once.
The standard treatment for intermediate-stage (BCLC B) hepatocellular carcinoma that cannot be resected, ablated or transplanted, exploiting the fact that tumours draw blood from the hepatic artery while normal liver relies on the portal vein. Drug-eluting beads deliver doxorubicin more slowly than conventional lipiodol emulsions. Combining TACE with immunotherapy and anti-VEGF drugs (EMERALD-1, LEAP-012) improves progression-free survival, and TACE is also used to bridge patients to liver transplantation.
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not linked directly; found by shared links- TermPortal vein tumour thrombus (macrovascular invasion)
Shares TARE / SIRT (radioembolisation with yttrium-90), BCLC staging, Transarterial chemoembolisation (TACE), Hepatocellular carcinoma.
- TermDownstaging and conversion therapy
Shares BCLC staging, Transarterial chemoembolisation (TACE), Hepatocellular carcinoma.
- TermChild-Pugh and ALBI liver-function scores
Shares BCLC staging, Hepatocellular carcinoma.
- TechnologyPercutaneous hepatic perfusion (chemosaturation)
Shares Liver-directed therapy (TACE, TARE, HAI, ablation), Transarterial chemoembolisation (TACE), Neuroendocrine tumours.
- CompanyBoston Scientific
Shares Transarterial chemoembolisation (TACE), Hepatocellular carcinoma.
- TrialEMERALD-1
Shares Transarterial chemoembolisation (TACE), Hepatocellular carcinoma.
- TrialLEAP-012
Shares Transarterial chemoembolisation (TACE), Hepatocellular carcinoma.
- TermCirrhosis
Shares BCLC staging, Hepatocellular carcinoma.