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This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.
This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.
Interventional study registered as NCT04711109, sponsored by Alliance for Clinical Trials in Oncology. Registry phase: 3. Registry enrollment is 300 participants (estimated). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-10. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
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