Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma

Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma is a phase 2/3, randomised interventional study registered as NCT04749108 by Institut du Cancer de Montpellier - Val d'Aurelle, with a registry enrolment figure of 1075 participants, started 2021-11-26 and due to reach its primary completion in 2029-09. Interventions recorded: Induction chemotherapy - modified FOLFIRINOX regimen; Early tumor response evaluation by MRI volumetry; Radiochemotherapy Cap 50; Radical proctectomy with total mesorectal excision. Conditions listed: Locally Advanced Malignant Neoplasm; Rectal Carcinoma. Primary outcome: R0 resection rate (R0 is defined as Circumferential resection margin (CRM ≥ 1 mm) for Phase II; 3-year Disease free survival (DFS) for Phase III. Colorectal eligibility wording from the registry: "Histologically confirmed diagnosis of adenocarcinoma of the rectum,". Sites: France. No results are recorded here; the registry entry is the source.