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This study adds tucatinib after local treatment for cancer progression in the brain while continuing selected HER2-directed therapy. It follows further progression in people whose cancer outside the brain remains controlled.
This study adds tucatinib after local treatment for cancer progression in the brain while continuing selected HER2-directed therapy. It follows further progression in people whose cancer outside the brain remains controlled.
Interventional study registered as NCT05323955, sponsored by Carey Anders, M.D.. Registry phase: 2. Registry enrollment is 48 participants (estimated). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-10. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Tucatinib, Trastuzumab emtansine, UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares Trastuzumab emtansine, Pertuzumab, UCSF Helen Diller Family Comprehensive Cancer Center, Trastuzumab and the tags ucsf-breast-coverage, interventional.
Shares Trastuzumab emtansine, UCSF Helen Diller Family Comprehensive Cancer Center, Trastuzumab, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares Pertuzumab, UCSF Helen Diller Family Comprehensive Cancer Center, Trastuzumab, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
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