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A phase 2/3 trial of capecitabine, fluorouracil (5-FU), leucovorin (folinic acid), fOLFIRI (5-FU, leucovorin, irinotecan) and other drugs in colorectal cancer, run by Alliance for Clinical Trials in Oncology, active but no longer recruiting.
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing Response is a phase 2/3, randomised interventional study registered as NCT05610163 by Alliance for Clinical Trials in Oncology, with a registry enrolment figure of 760 participants, started 2022-12-08 and due to reach its primary completion in 2026-09-30. Interventions recorded: Capecitabine; 5-fluorouracil; Leucovorin calcium; Irinotecan; Oxaliplatin; Long Course Chemoradiotherapy; Computed Tomography; Magnetic Resonance Imaging; Sigmoidoscopy; biopsy. Conditions listed: Stage II Rectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Locally Advanced Rectal Adenocarcinoma. Primary outcome: Clincal Complete Response (cCR) Rates (Phase II); Disease-free survival (DFS) rate (Phase III). Colorectal eligibility wording from the registry: "* Histologic Documentation: rectal adenocarcinoma, mismatch repair proficient (pMMR)". Sites: Puerto Rico, United States. No results are recorded here; the registry entry is the source.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine and the tag colorectal-deep-dive.
Shares Alliance for Clinical Trials in Oncology, FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), FOLFOX (5-FU, leucovorin, oxaliplatin) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Leucovorin (folinic acid), FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU) and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), FOLFOX (5-FU, leucovorin, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Platinum agents and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, FOLFOX (5-FU, leucovorin, oxaliplatin), Capecitabine, Platinum agents and the tag colorectal-deep-dive.