Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial is a phase 3, randomised interventional study registered as NCT06500481 by NRG Oncology, with a registry enrolment figure of 115 participants, started 2025-03-04 and due to reach its primary completion in 2028-07-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Involved-Field Radiation Therapy; Lumbar Puncture; Magnetic Resonance Imaging; Positron Emission Tomography; Proton Beam Craniospinal Irradiation; Quality-of-Life Assessment. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Leptomeninges; Stage IV Lung Cancer AJCC v8. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: "* Patients with pathologically (histologically or cytologically) proven diagnosis of breast cancer or NSCLC". Sites: United States. No results are recorded here; the registry entry is the source.