Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.

Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. is a phase 2/3, randomised interventional study registered as NCT06758830 by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos, with a registry enrolment figure of 400 participants, started 2025-01-06 and due to reach its primary completion in 2029-12-27. Interventions recorded: Radiation Therapy; Chemoradiotherapy; Consolidation Chemotherapy; Surgery; Part two; Adjuvant treatment. Conditions listed: Rectal Cancer; Total Neoadjuvant Treatment; Neoadjuvant Therapy; Radiotherapy; Chemotherapy; Organ Preservation; Radiotherapy Side Effect; Chemotherapy Side Effects; Chemoradiotherapy; Low Anterior Resection Syndrome; Quality of Life. Primary outcome: Postoperative complications; TNT toxicity; Mortality rate. Colorectal eligibility wording from the registry: "* Pathologically confirmed rectal adenocarcinoma". Sites: Lithuania. No results are recorded here; the registry entry is the source.