A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course R

A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT07113275 by Tao Zhang, with a registry enrolment figure of 444 participants, started 2026-05-15 and due to reach its primary completion in 2028-01-01. Interventions recorded: Short-course radiotherapy; Long-course radiotherapy; Capecitabine; Oxaliplatin; HLX10; TME surgery; HLX10 placebo. Conditions listed: Rectal Cancer; Total Neoadjuvant Therapy; Radiotherapy; Immunotherapy. Primary outcome: 3-year event-Free Survival. Colorectal eligibility wording from the registry: "Histologically confirmed Locally Advanced rectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.