Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced

Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07581626 by Chinese PLA General Hospital, with a registry enrolment figure of 60 participants, started 2026-05-01 and due to reach its primary completion in 2027-04-01. Interventions recorded: SCRT+targeted therapy+immunotherapy+chemotherapy. Conditions listed: Locally Advanced Rectal Cancer (LARC). Primary outcome: Complete Response (CR). Colorectal eligibility wording from the registry: "* Middle or low rectal cancer located ≤10 cm from the anal verge as assessed by MRI". Sites: China. No results are recorded here; the registry entry is the source.