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A phase 2 trial of olomorasib, cetuximab, fOLFOX (5-FU, leucovorin, oxaliplatin) and fluorouracil (5-FU) in colorectal cancer, run by Eli Lilly and Company, not yet recruiting.
A Study of Olomorasib (LY3537982) in Participants With Advanced Colorectal Cancer and a KRAS G12C Mutation is a phase 2, interventional study registered as NCT07814417 by Eli Lilly and Company, with a registry enrolment figure of 50 participants, started 2026-10 and due to reach its primary completion in 2028-11. Interventions recorded: Olomorasib; Cetuximab; Oxaliplatin; Leucovorin/levofolinate calcium; 5-fluorouracil. Conditions listed: Colorectal Neoplasms. Primary outcome: Overall Response Rate (ORR) Per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1; Progression-Free Survival (PFS) Per RECIST v1.1. Colorectal eligibility wording from the registry: "* Histologically or cytologically confirmed colorectal cancer (CRC) with Stage III or Stage IV disease, not suitable for curative intent radical surgery or radiation therapy". No results are recorded here; the registry entry is the source.
Shares Cetuximab, FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU), Platinum agents and the tag colorectal-deep-dive.
Shares Cetuximab, FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Monoclonal antibodies and the tag colorectal-deep-dive.
Shares Cetuximab, FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Monoclonal antibodies and the tag colorectal-deep-dive.
Shares KRAS G12C-mutant colorectal cancer, KRAS & RAS inhibitors, Cetuximab, Monoclonal antibodies and the tag colorectal-deep-dive.
Shares Cetuximab, Fluorouracil (5-FU), Monoclonal antibodies, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Fluorouracil (5-FU), Platinum agents, Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.