Ionis Pharmaceuticals
Ionis is the Carlsbad company that made antisense oligonucleotides into medicines; its cancer programmes, including the clusterin antisense custirsen developed with OncoGenex and the STAT3 antisense danvatirsen, reached late trials without approval.
Overview
Ionis Pharmaceuticals, founded in 1989 as Isis Pharmaceuticals and based in Carlsbad, California, pioneered antisense oligonucleotide drugs, with approvals in spinal muscular atrophy, transthyretin amyloidosis and other rare diseases through partners. In oncology it co-developed custirsen (OGX-011), whose phase 3 trials failed, and tested the STAT3 antisense danvatirsen with checkpoint inhibitors through AstraZeneca. ClinicalTrials.gov lists Ionis as lead sponsor of a phase 3 cancer trial.
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