Clinical trial
A research study that tests a treatment in volunteers under strict rules, to find out whether it is safe and whether it works. Every approved cancer drug went through several.
Trials have a written protocol specifying who may join, what they receive, what is measured and how the results will be analysed, and are overseen by ethics committees and regulators; participants give informed consent and are usually monitored more closely than in routine care. Cancer trials progress through phases, from small safety studies to large randomised comparisons against the standard of care, and their results, reported at congresses such as ASCO and ESMO and in journals, are what change practice and win approvals. Fewer than one in ten adult cancer patients take part, participation is skewed towards younger, wealthier and white patients, and the cost and duration of trials is one of the field's main bottlenecks.
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not linked directly; found by shared links- TermModel organism
Shares In vitro and in vivo, Preclinical.
- TermP-value
Shares Randomised trial, Endpoint.
- TermCell line
Shares In vitro and in vivo, Preclinical.
- TermOrganoid
Shares In vitro and in vivo, Preclinical.
- TermConfidence interval
Shares Randomised trial, Endpoint.
- TermSurrogate endpoint
Shares Phase 1, 2 and 3 trials, Endpoint.
- TechnologyDigital twins and virtual control arms
Shares AI trial matching & clinical decision support, Basket, umbrella, and platform trials, Real-world evidence.
- IdeaJust-in-time site activation: open a site in two weeks when a patient appears
Shares AI trial matching & clinical decision support, Basket, umbrella, and platform trials.