SillaJen is a South Korean company that began with viruses engineered to infect and kill cancer cells. Its newest medicine, BAL0891, is a tablet-type drug that blocks two enzymes cancer cells need to divide, and the FDA gave it orphan drug status for acute myeloid leukaemia in 2026.
SillaJen, Inc. has its head office at 106 Cheonggyecheon-ro in Seoul, a research centre in Gwanggyo, a pharmaceutical division in Suwon and an office in San Diego, according to its website, which describes it as developing oncolytic immunotherapeutics. Its pipeline page lists BAL0891, a dual TTK and PLK1 inhibitor (the page cites a 2022 Basilea presentation as a source), alongside oncolytic vaccinia virus programmes. The company says BAL0891 is in a phase 1 dose-escalation trial in relapsed or refractory solid tumours (NCT05768932, which ClinicalTrials.gov lists as also enrolling relapsed or refractory acute myeloid leukaemia). On 24 August 2026 the FDA granted orphan drug designation for the treatment of acute myeloid leukaemia to a product the database describes as a small-molecule mitotic checkpoint inhibitor with dual inhibition of TTK and PLK1; the company's website headlines the designation as one for BAL0891.
BAL0891 is an experimental medicine from SillaJen that blocks two enzymes cancer cells use to divide. It is in an early trial, and the FDA has given it orphan drug status for acute myeloid leukaemia.
Shares MPS1 (TTK), PLK1.
Shares MPS1 (TTK), PLK1.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/