BUB1
BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
Overview
BUB1 (chromosome 2q13) is a serine/threonine kinase essential for spindle-assembly-checkpoint signalling and correct chromosome alignment: it assembles checkpoint proteins at the kinetochore, being required for the localisation of CENPF, BUB1B, CENPE and MAD2L1 and of PLK1, and for centromeric enrichment of cohesion factors. Expression is high in testis and thymus, lower in colon, spleen, lung and small intestine, and associated with tissues of high mitotic index (UniProt O43683). A ClinicalTrials.gov search for the tool inhibitor BAY 1816032 returned no studies.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
- 1 · What it is
BUB1 is one of the kinases that stops a dividing cell pulling its chromosomes apart before every one is attached. Inhibitors exist in the laboratory; none has reached patients.
- 2 · What goes wrong in cancer
A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.
- 3 · How drugs use it
No product in this corpus aims at BUB1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:1148 (approved symbol, name, aliases and cross-references); UniProt O43683 (protein name, function and tissue specificity)
Biology
A kinetochore kinase of the spindle assembly checkpoint, alongside MPS1 (TTK) and BUB1B.
- Tissues with a high mitotic index (UniProt O43683)
Notes
top- Prevalence not recorded: HGNC and UniProt carry no positivity rates.
Latest papers
topQuery for this target: (TITLE:"BUB1" OR ABSTRACT:"BUB1" OR TITLE:"BUB1 mitotic checkpoint serine/threonine kinase" OR ABSTRACT:"BUB1 mitotic checkpoint serine/threonine kinase" OR TITLE:"hBUB1" OR ABSTRACT:"hBUB1" OR TITLE:"BUB1L" OR ABSTRACT:"BUB1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BUB1, not a curated reading list.
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