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T-Knife
A Berlin company that engineers patients' T cells with receptors that recognise cancer, aiming at solid tumours. Its lead therapy targets PRAME, a marker found in many cancers, and its first trial is planned for 2026.
Also called: T-knifeT-knife TherapeuticsT-knife GmbHT-knife Therapeutics, Inc.
Overview
T-Knife develops engineered T-cell therapies for solid tumours. Its lead candidate is a TCR-T therapy targeting PRAME, which the company says is found in cancers of the skin, uterus, ovaries, lungs, breasts, oesophagus, kidneys, cervix and head and neck; the T cells carry the company's added enhancements meant to improve fitness and persistence in the tumour. The company says a Phase 1 trial is planned to begin in 2026 after CTA approval, and it lists in vivo programmes as well. T-Knife was founded on technology from the Max Delbruck Center for Molecular Medicine and Charite, with co-founders Thomas Blankenstein and Elisa Kieback. An earlier Phase 1/2 trial of MAGE-A1-directed TCR-T cells in advanced solid tumours (NCT05430555, sponsor T-knife GmbH) is registered as terminated.
Notes
- Founding year not stated on the pages read.
- Andera Partners is added because its life sciences page carries a T-Knife testimonial among its portfolio companies; check whether that is enough.
- No product record: the PRAME TCR-T candidate is preclinical and NCT05430555 does not name a product code.
- Cancer ids left empty because no trial of the PRAME TCR-T candidate is registered.
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6Similar pages
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- TargetHLA-A
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Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
anderapartners.com · 1
ClinicalTrials.gov · 1
racap.com · 1
A source that has moved or gone is reported by the weekly link check. /audit/