Claudin 6
A tight-junction protein normally found only in the embryo that reappears in ovarian, testicular, endometrial and lung cancers, making it a clean target for ADCs and CAR-T. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Four-transmembrane tight-junction claudin expressed in embryonic epithelia and germ cells; silenced after development, re-expressed in cancers via epigenetic derepression.
- Ovarian cancer (~50-60%)
- Testicular germ cell tumours (>90%)
- Endometrial cancer (~30%)
- NSCLC adenocarcinoma and gastric cancer (subsets)
Elsewhere: identifiers and databases
Built from HGNC, Ensembl, UniProt and ChEMBL idsHow common it is, by cancer
Full matrix →| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Testicular germ cell tumours | 90% | IHC positivity | ||
| Ovarian cancer | 50-60% | IHC positivity | varies by antibody and cutoff |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Products by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes that involve this target
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways where it is a node
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics and assays
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Key papers and the live literature
Preprints →Query for this target: (TITLE:"Claudin 6" OR ABSTRACT:"Claudin 6" OR TITLE:"CLDN6" OR ABSTRACT:"CLDN6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Claudin 6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cldn6.json. Licence CC BY 4.0.