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LSD1 is an enzyme that removes small chemical tags from the proteins DNA is wound around, switching genes off or on. Many cancers carry a lot of it and it helps keep leukaemia cells immature; several LSD1 inhibitors have been tested in blood cancers and solid tumours. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Flavin-dependent amine oxidase that demethylates mono- and dimethylated H3K4 (a mark of active genes) and, with partners, H3K9; it also acts on non-histone proteins (UniProt O60341).
| Modality | Phase 1 |
|---|---|
| Small molecule 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 1 | Recruiting | A Phase 1, Multicenter, Open-Label, Dose-Escalation Study to Assess Safety, Tolerability, and Efficacy of EXS74539 as Monotherapy in Participants With Select Solid Tumors | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"LSD1" OR ABSTRACT:"LSD1" OR TITLE:"KDM1A" OR ABSTRACT:"KDM1A" OR TITLE:"lysine-specific demethylase 1" OR ABSTRACT:"lysine-specific demethylase 1" OR TITLE:"lysine demethylase 1A" OR ABSTRACT:"lysine demethylase 1A" OR TITLE:"AOF2" OR ABSTRACT:"AOF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LSD1 (KDM1A), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/lsd1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/lsd1.json. Licence CC BY-NC 4.0.