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REC-4539 is an experimental small molecule LSD1 inhibitor from Recursion Pharmaceuticals, in phase 1 trials for small-cell lung cancer, acute myeloid leukaemia and solid tumours.
REC-4539 (EXS74539) is a small molecule LSD1 inhibitor from Recursion Pharmaceuticals. Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant. Its furthest stage is phase 1, for small-cell lung cancer, acute myeloid leukaemia and solid tumours. ClinicalTrials.gov registers it in one study linked below. Pipeline page: 'Status: Phase 1'. Registry NCT07517198 recruiting (sponsor Exscientia AI Ltd., a wholly owned subsidiary of Recursion). Whether it works in people has not been established unless a trial below reports it.
Described by the company as the first LSD1 inhibitor designed to be both reversible and CNS-penetrant. Connects to LSD1 (KDM1A).
1.REC-4539 slips into a pocket on LSD1 (KDM1A).
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Query for this drug: (TITLE:"REC-4539" OR ABSTRACT:"REC-4539" OR TITLE:"EXS74539" OR ABSTRACT:"EXS74539") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about REC-4539, not a curated reading list.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals and the tag pipeline.
Shares Recursion Pharmaceuticals and the tag pipeline.
Shares Recursion Pharmaceuticals and the tag pipeline.
Shares Small-cell lung cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
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